Compounds

Blocks CB1 at low doses and flips to agonism at higher doses, giving dose-dependent effects.

The raw acidic precursor to THC; non-binding at CB1 until decarboxylated by heat.

Binds CB1 receptors throughout the central nervous system, mimicking the endocannabinoid anandamide to alter neurotransmitter release.

A double-bond isomer of Δ9-THC with lower CB1 affinity, producing a milder, clearer high.

An oxidative degradation product of THC with mild affinity for cannabinoid receptors.

The 'mother cannabinoid' — enzymatically converted by the plant into THCA, CBDA and CBCA.

Acts as a partial agonist at cannabinoid receptors and inhibits GABA reuptake via α2 pathways.

A selective COX-2 inhibitor and potent serotonin receptor agonist found in raw flower.

Modulates serotonin and vanilloid receptors while dampening CB1 signaling without acting as a direct agonist.

Activates TRPA1 channels and raises endocannabinoid tone by blocking anandamide reuptake.