Cannabinoid
THCA
Tetrahydrocannabinolic acid
C₂₂H₃₀O₄
358.47 g/mol Non-intoxicating (raw)
Typical abundancemajor
Receptor targets
Minimal CB1 affinity (non-intoxicating raw precursor)
Mechanism of action
The dominant cannabinoid in raw, unheated flower. It does not fit CB1 well and is non-intoxicating until heat drives decarboxylation into THC.
Reported effects
Research
Preclinical; anti-inflammatory and neuroprotective activity reported for the raw acid.