Cannabinoid
CBL
Cannabicyclol
C₂₁H₃₀O₂
314.47 g/mol Non-intoxicating
Typical abundancetrace
Receptor targets
5-HT1A (positive allosteric modulator) · weak CB1/CB2
Mechanism of action
A photochemical degradation product of CBC: UV light drives an intramolecular cyclisation that fuses a cyclobutane ring onto the skeleton. It binds the cannabinoid receptors only weakly.
Reported effects
Common terpenes
Research
Long assumed inert, but a 2025 study (J. Nat. Prod.) found CBL is a potent positive allosteric modulator of the 5-HT1A serotonin receptor — its first documented activity.