THCA

Tetrahydrocannabinolic acid

C₂₂H₃₀O₄ 358.47 g/mol Non-intoxicating (raw)

Typical abundancemajor

Receptor targets

Minimal CB1 affinity (non-intoxicating raw precursor)

Mechanism of action

The dominant cannabinoid in raw, unheated flower. It does not fit CB1 well and is non-intoxicating until heat drives decarboxylation into THC.

Reported effects

Anti-inflammatory (preclinical)

Research

Preclinical; anti-inflammatory and neuroprotective activity reported for the raw acid.