Δ8-THC

Δ8-Tetrahydrocannabinol

C₂₁H₃₀O₂ 314.46 g/mol Intoxicating (milder than Δ9)

Typical abundancetrace

Receptor targets

CB1 · CB2 (partial agonist, lower potency than Δ9)

Mechanism of action

A Δ9-THC isomer with the double bond shifted to the 8-position. It binds CB1 with somewhat lower potency, giving a milder intoxication. Most commercial Δ8 is semi-synthesised from CBD.

Reported effects

Euphoria (mild)Anti-nausea (preclinical)

Research

Limited; the consumer market is largely hemp-derived and semi-synthetic, and its legal status is contested in many jurisdictions.